{"id":2655,"date":"2026-09-14T14:58:22","date_gmt":"2026-09-14T12:58:22","guid":{"rendered":"https:\/\/peptelia.com\/semax-kaufen-leitfaden\/"},"modified":"2026-10-10T23:56:46","modified_gmt":"2026-10-10T21:56:46","slug":"semax-buying-guide","status":"publish","type":"post","link":"https:\/\/peptelia.com\/en\/semax-buying-guide\/","title":{"rendered":"Buying Semax: the ACTH(4-10) Analogue, How It Differs from Selank and What Labs Check"},"content":{"rendered":"<p><strong>In brief:<\/strong> Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic peptide that extends fragment 4\u201310 of adrenocorticotropic hormone (ACTH) with the stabilising sequence Pro-Gly-Pro \u2013 the same \u201cprotective cap\u201d that Selank carries. In research it is used as a model compound for neurotrophic and neuroprotective signalling pathways; it is not approved as a medicinal product in the EU and is available exclusively for research use. When sourcing it, what counts is a batch-specific COA with HPLC and mass spectrometry, the net peptide content and oxidation-aware storage, because Semax contains methionine, a sensitive residue.<\/p>\n<h2>What is Semax?<\/h2>\n<p>Semax was developed \u2013 like Selank \u2013 at the Institute of Molecular Genetics of the Russian Academy of Sciences. The starting point is the ACTH fragment 4\u201310 (Met-Glu-His-Phe-Arg-Trp-Gly), which has been investigated in animal models in studies of learning and attention paradigms without producing the hormonal effect of full-length ACTH. Replacing the C-terminal end with Pro-Gly-Pro produced a heptapeptide with markedly higher enzymatic stability. Semax is registered as a medicinal product in Russia, but not in the EU or the United States.<\/p>\n<p>In the scientific literature, Semax is studied above all in connection with:<\/p>\n<ul>\n<li>the expression of neurotrophic factors (BDNF, NGF) and their receptors in the hippocampus<\/li>\n<li>neuroprotective mechanisms in ischaemia models<\/li>\n<li>modulation of the melanocortin system and of gene expression in the CNS<\/li>\n<\/ul>\n<p>Structure, receptor profile and literature references are summarised on the <a href=\"https:\/\/peptelia.com\/en\/library\/semax\/\">Semax page in the peptide library<\/a>.<\/p>\n<h2>Semax and Selank compared<\/h2>\n<p>The two peptides are often mentioned in the same breath, because they come from the same institute and carry the same stabilising sequence. As research tools, however, they address different questions:<\/p>\n<table>\n<thead>\n<tr>\n<th><\/th>\n<th>Semax<\/th>\n<th>Selank<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Origin<\/td>\n<td>ACTH fragment 4\u201310<\/td>\n<td>Tuftsin (IgG fragment)<\/td>\n<\/tr>\n<tr>\n<td>Sequence<\/td>\n<td>Met-Glu-His-Phe-Pro-Gly-Pro<\/td>\n<td>Thr-Lys-Pro-Arg-Pro-Gly-Pro<\/td>\n<\/tr>\n<tr>\n<td>Molecular mass<\/td>\n<td>approx. 814 Da<\/td>\n<td>approx. 751 Da<\/td>\n<\/tr>\n<tr>\n<td>Typical research fields<\/td>\n<td>Neurotrophic factors, neuroprotection, melanocortin system<\/td>\n<td>GABAergic modulation, stress models, immune-nervous axis<\/td>\n<\/tr>\n<tr>\n<td>Sensitive residue<\/td>\n<td>Methionine (prone to oxidation)<\/td>\n<td>\u2013<\/td>\n<\/tr>\n<tr>\n<td>Formats at Pept\u00e9lia<\/td>\n<td>Vial 5 mg \/ 10 mg<\/td>\n<td>Vial 5 mg \/ 10 mg, ready-made solution 20 mg \/ 10 ml<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Anyone planning to compare the two compounds in one model should choose batches with comparable documentation \u2013 ideally from the same testing laboratory. The guide to the second compound is available at <a href=\"https:\/\/peptelia.com\/en\/selank-buying-guide\/\">Buying Selank: vial or ready-made solution?<\/a>.<\/p>\n<h2>What labs should check when sourcing<\/h2>\n<ol>\n<li><strong>Batch-specific COA with HPLC and MS.<\/strong> The lot number on the certificate has to match the vial; the chromatogram shows the purity, and mass spectrometry confirms the identity (target mass around 814 Da). A percentage figure without a chromatogram is not evidence \u2013 see the <a href=\"https:\/\/peptelia.com\/en\/your-coa-guide\/\">COA guide<\/a>.<\/li>\n<li><strong>Oxidation status.<\/strong> The methionine residue in position 1 can oxidise to the sulfoxide; in the mass spectrum this shows up as a +16 Da signal. A clean COA shows this peak either not at all or only minimally. If you cannot place this point in the chromatogram, the basics are covered in the article on <a href=\"https:\/\/peptelia.com\/en\/peptide-degradation-pathways\/\">degradation pathways in the mass spectrum<\/a>.<\/li>\n<li><strong>Net peptide content.<\/strong> As with all small peptides, what counts for the concentration calculation is the net content, not the HPLC purity. Calculation aid: <a href=\"https:\/\/peptelia.com\/en\/peptide-calculator\/\">peptide calculator<\/a>.<\/li>\n<li><strong>Legal framework.<\/strong> Semax is not approved as a medicinal product in the EU and is supplied exclusively for research use (Research Use Only; not legal advice, observe national regulations). Background in our <a href=\"https:\/\/peptelia.com\/en\/research-disclaimer\/\">research use disclaimer<\/a>.<\/li>\n<\/ol>\n<h2>Storage: methionine calls for care<\/h2>\n<p>Lyophilised Semax belongs at \u221220 \u00b0C, dry, dark and as far as possible protected from atmospheric oxygen \u2013 so do not leave the vial open any longer than necessary after opening it. Reconstitute with bacteriostatic water, slowly down the vial wall and without shaking; the solution is kept refrigerated and frozen in aliquots, to avoid repeated thawing. General rules in <a href=\"https:\/\/peptelia.com\/en\/storage-stability\/\">storing peptides correctly<\/a>.<\/p>\n<h2>Semax at Pept\u00e9lia<\/h2>\n<p>Pept\u00e9lia stocks Semax as a lyophilised vial in <a href=\"https:\/\/peptelia.com\/en\/products\/semax-neuropeptide-5mg\/\">5 mg<\/a> (\u20ac29.90) and <a href=\"https:\/\/peptelia.com\/en\/products\/semax-neuropeptide-10mg\/\">10 mg<\/a> (\u20ac34.90). Every batch is tested in our own lab by HPLC and UV\/Vis spectroscopy, and the COA can be viewed before purchase. Dispatch on the next business day from the EU, free shipping from \u20ac100, and bacteriostatic water is included with every order. For an overview: <a href=\"https:\/\/peptelia.com\/en\/product-category\/neurocognitive-research\/semax\/\"><strong>buy Semax<\/strong><\/a>.<\/p>\n<p><em>Note: For research use only (Research Use Only) \u2013 not for use in humans or animals.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Semax is a synthetic heptapeptide based on the ACTH fragment 4\u201310, used in research mainly as a model compound for neurotrophic signalling pathways. This guide covers its origin and research fields, how it differs from Selank, the checks to run when sourcing it and correct storage.<\/p>\n","protected":false},"author":2,"featured_media":1724,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2655","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-unkategorisiert"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Buying Semax: Lab Guide to the ACTH Analogue | Pept\u00e9lia<\/title>\n<meta name=\"description\" content=\"Semax buying guide for labs: ACTH(4-10) origin, differences from Selank, COA and HPLC checks, methionine oxidation and correct storage. 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