{"id":217,"count":3,"description":"<strong>Buy KPV<\/strong> \u2013 KPV is the tripeptide Lys-Pro-Val, corresponding to the C-terminal fragment 11\u201313 of alpha-melanocyte-stimulating hormone. Unlike full-length alpha-MSH, KPV is regarded in the literature as largely independent of the classical melanocortin receptors MC1R to MC5R; an intracellular site of action is discussed instead, along with transport via PepT1 in epithelial cells. As a model substance, KPV serves to examine modulation of the NF-kB pathway and expression of IL-8 and TNF-alpha in intestinal epithelial lines such as Caco-2 and HT-29. Further questions concern keratinocyte and fibroblast cultures and scratch-assay models of cell migration. The decisive difference from the parent hormone is practical: the short, unmodified tripeptide is easier to synthesise, shows no pigmentation effects and is more robust towards heat and lyophilisation than the tridecapeptide alpha-MSH. KPV dissolves in water and physiological buffers; because of the basic lysine residue, the pH of the stock solution requires attention. At Pept\u00e9lia it is available as a lyophilisate in a vial, with reconstitution and storage details on the product page. Related peptides for tissue models appear under Regenerative Research. Each batch is tested in-house by HPLC and UV\/Vis spectroscopy, and the batch certificate of analysis is viewable before purchase. <strong>For research use only. Not for use in or on the human body.<\/strong>","link":"https:\/\/peptelia.com\/en\/product-category\/regenerative-research\/kpv\/","name":"KPV","slug":"kpv","taxonomy":"product_cat","parent":227,"meta":[],"menu_order":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>KPV kaufen \u2013 Forschungspeptid mit COA | Pept\u00e9lia<\/title>\n<meta name=\"description\" content=\"KPV Tripeptid f\u00fcr die Forschung zu entz\u00fcndungsassoziierten Signalwegen. 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