Buy 5-Amino-1MQ

Buy 5-Amino-1MQ – 5-Amino-1MQ is not a peptide but a small-molecule quinolinium derivative: a methylated quinoline carrying an amino group at position 5, described as a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide and therefore intersects both the NAD salvage pathway and the cellular methyl-group budget. In basic research the compound serves as a model substance for examining the relationship between NNMT activity, intracellular NAD levels and sirtuin-dependent signalling. It is studied in adipocyte cultures such as 3T3-L1, in hepatocyte models and in tumour cell lines with high NNMT expression, where questions of methylation flux, energy metabolism and gene expression are central. Worth noting is the contrast with peptide compounds: as a small molecule with a quaternary nitrogen, 5-Amino-1MQ is readily water-soluble, yet stock solutions are commonly prepared in DMSO, and short-term handling needs no peptide-style cold chain. Peptélia supplies the substance as a lyophilisate in a vial, with reconstitution and storage details on the product page. Further compounds related to energy metabolism appear in the parent category Metabolic Research. Each batch is tested in-house by HPLC and UV/Vis spectroscopy; the batch-specific certificate of analysis is available before purchase. For research use only. Not for use in or on the human body.