GHK-Cu denotes the copper complex of the tripeptide glycyl-L-histidyl-L-lysine (GHK). The peptide consists of just three amino acids and binds divalent copper ions via its histidine and lysine residues to form a stable complex – hence the widely used term „copper peptide“. GHK was originally described as a naturally occurring sequence in human blood plasma and is today among the most frequently studied small peptides of all.
For research purposes, GHK-Cu is produced fully synthetically: the tripeptide is obtained by peptide synthesis and subsequently complexed with copper(II). Characteristic is the intense blue colour of the complex in solution. As a traded item, GHK-Cu is a research chemical without approval as a medicine and is offered exclusively for use in the laboratory.
Profile
Molecule type: copper(II) complex of a tripeptide
Number of amino acids: 3 (glycine, histidine, lysine)
Distinctive feature: high affinity for copper ions, blue complex colour in solution
Research classification: research chemical, Research Use Only (RUO)
Research context
GHK-Cu has been studied scientifically since the 1970s. One focus of the published research lies in cell biology: among the questions examined are how the copper complex interacts with fibroblasts and other cell types in cell culture models, and what role copper binding might play in transport and signalling processes at the cellular level.
Further research fields concern gene expression – several studies have analysed how gene activity patterns change in cell models under GHK exposure – as well as basic research on the extracellular matrix and on skin models in vitro. The substance is also present as a subject of investigation in cosmetics research. All of these findings come from experimental models; they are described in the preclinical literature and describe ongoing research, and these findings do not support conclusions about effects in humans.
Quality criteria for laboratory procurement
When obtaining GHK-Cu for research purposes, every batch should be supported by a certificate of analysis (COA). Alongside the HPLC purity of the peptide, the correct identity also matters for a copper complex and is typically confirmed by mass spectrometry. Reputable suppliers additionally document batch numbers so that every container can be assigned to a specific test report.
GHK-Cu is usually supplied lyophilised and should be stored dry, cool and protected from light. For longer storage, keeping it in the laboratory freezer is common practice; prepared solutions are, as a rule in research, used fresh or frozen in aliquots.
Frequently asked questions
Is GHK-Cu legally available?
GHK-Cu can legally be obtained as a research chemical for scientific purposes. It is neither a medicine nor an approved cosmetic product; supply is exclusively for use in the laboratory. Anyone obtaining GHK-Cu must observe the national regulations applicable to research materials.
What should be checked on the COA?
The certificate should contain the batch number, the purity determined chromatographically and mass-spectrometric confirmation of identity. For a copper complex it is additionally helpful if the manufacturer states the complex form or the copper content.
How is GHK-Cu stored?
The lyophilised material belongs in a dry, cool place protected from light; for long-term storage the freezer is customary. A tightly sealed container is important, because moisture can impair the stability of lyophilised peptides.
Available at Peptélia
Peptélia offers GHK-Cu as batch-documented research material with a certificate of analysis (COA). An overview of the available products can be found in the GHK-Cu category at Peptélia.
Important notice
All substances offered by Peptélia are intended exclusively for scientific use in the laboratory (Research Use Only). They are not medicines, not food supplements and not cosmetics. Use in humans or animals, as well as any diagnostic or therapeutic use, is expressly excluded.
For research use only. Not for use in or on the human body.
