Buy ACE-031

Buy ACE-031 – ACE-031 is a recombinant fusion protein combining the extracellular domain of activin receptor type IIB (ActRIIB) with the Fc fragment of a human IgG1. Acting as a soluble receptor decoy, the construct binds ligands of the TGF-beta superfamily, among them myostatin (GDF-8), activin A and GDF-11, before they reach membrane-bound receptors. In basic research ACE-031 therefore serves as a model substance for mapping ligand selectivity across the ActRIIB axis, for interrupting the downstream SMAD2/3 cascade in myoblast and fibroblast cultures, and for separating the contribution of individual ligands in cell and animal models. The literature also describes how the Fc portion extends residence time in model systems compared with soluble receptor fragments lacking Fc, and what cross-reactivity toward related type II receptors occurs. Structurally, ACE-031 stands clearly apart from the short-chain peptides of this section, which act on pituitary G protein-coupled receptors. Peptélia supplies the substance as a lyophilisate in a vial, with reconstitution and storage details on the product page; related working materials are grouped under the parent section Growth Factor Research. Each batch is tested in-house by HPLC and UV/Vis spectroscopy; the batch-specific certificate of analysis is available before purchase. For research use only. Not for use in or on the human body.