Buy Tesamorelin

Buy Tesamorelin – Tesamorelin is a stabilised analogue of human GHRH(1-44) in which the N-terminus is acylated with a trans-3-hexenoic acid group. This modification sterically shields the cleavage site accessible to dipeptidyl peptidase IV without altering the binding domain for the GHRH receptor. As a model compound, tesamorelin is used to elucidate structure-activity relationships at the GHRH receptor, to compare the enzymatic stability of acylated peptides in buffer and plasma models, and to record downstream transcription profiles of the IGF-1 axis in hepatocyte and adipocyte cultures. Technically interesting is the direct comparison of design principles: tesamorelin retains the full 44-amino-acid sequence and achieves its stability through a lipid modification, whereas CJC-1295 is based on the shortened 1-29 fragment with amino acid substitutions – two different chemical routes to addressing the same proteolytic problem experimentally in model systems. Peptélia supplies tesamorelin as a lyophilisate in a vial, with reconstitution and storage details on the product page; an overview of this field of work is given in the Growth Factor Research section. Each batch is tested in-house by HPLC and UV/Vis spectroscopy, and the batch-specific certificate of analysis is viewable before purchase. For research use only. Not for use in or on the human body.