Buy MOTS-C

Buy MOTS-C – MOTS-C is a 16-amino-acid peptide whose open reading frame is encoded not in the nucleus but in the mitochondrial 12S rRNA. It therefore belongs to the mitochondria-derived peptides and is described as an example of retrograde communication between organelle and nucleus. In research, MOTS-C serves as a model substance for examining how folate and methionine metabolism couple to the purine intermediate AICAR and downstream AMPK activation. Work is also reported on nuclear translocation under metabolic stress and on binding to stress-responsive transcription factors, frequently in skeletal muscle lines such as C2C12, primary myotubes and hepatocyte cultures. Practically relevant is the pronounced hydrophilicity of the sequence: it reconstitutes well in aqueous buffer but, owing to its basic residues, adsorbs to glass surfaces, so low-binding vessels or carrier protein additives are often used in assays. At Peptélia, MOTS-C is available as a lyophilisate in a vial, with reconstitution and storage details on the product page. For comparative work on other targets of energy metabolism, see the Metabolic Research category. Each batch is tested in-house by HPLC and UV/Vis spectroscopy, and the batch certificate of analysis is viewable before purchase. For research use only. Not for use in or on the human body.