Buy Thymosin Alpha-1

Buy Thymosin Alpha-1 – Thymosin Alpha-1 is a 28-amino-acid, N-terminally acetylated polypeptide that arises through proteolytic processing of the precursor prothymosin alpha and was originally described in thymus tissue. In basic research it serves as a model compound for studies on Toll-like receptors, in particular TLR2 and TLR9, on dendritic cells and monocytes. Further questions described in the literature concern the maturation of T-cell precursors in thymocyte co-cultures, cytokine expression patterns of interferon-gamma and interleukin-2 in stimulated cell cultures, and marker analyses by flow cytometry in rodent models. Characteristic is the strongly acidic, hydrophilic sequence with a high proportion of aspartic and glutamic acid, which accounts for good water solubility; the N-terminal acetylation distinguishes the molecule from the unmodified fragment of the precursor protein and influences recognition by aminopeptidases. Also relevant for laboratory practice is the tendency of short-chain acidic peptides to adsorb to glass and plastic surfaces. Peptélia supplies Thymosin Alpha-1 as a lyophilisate in a vial, with reconstitution and storage details on the product page. Thematically adjacent preparations are listed under Immunology Research. Each batch is tested in-house by HPLC and UV/Vis spectroscopy, and the batch-specific certificate of analysis is viewable before purchase. For research use only. Not for use in or on the human body.