Buy AOD-9604

Buy AOD-9604 – AOD-9604 is a synthetic peptide analogue corresponding to the C-terminal section 176–191 of human growth hormone, carrying an additional stabilising tyrosine residue at the N-terminus. The fragment lacks the domains essential for receptor binding of full-length hGH, which is why the literature discusses it as a model for receptor-independent effects of the hormone molecule. In basic research AOD-9604 is used to characterise lipolytic signalling pathways in isolated adipocytes, in particular the role of β3-adrenergic signalling and hormone-sensitive lipase. Further questions concern separating fragment activity from the IGF-1-mediated axis, and work in cartilage and chondrocyte models describing matrix-related markers. Instructive is the structural comparison with the native 176–191 fragment: the extra tyrosine residue improves handling and analytical detectability, while the disulfide bridge between the two cysteines fixes the loop conformation and makes the substance sensitive to reducing buffer conditions. Peptélia supplies AOD-9604 as a lyophilisate in a vial, with reconstitution and storage details on the product page. Thematically related sequences are reachable through the parent category Metabolic Research. Each batch is tested in-house by HPLC and UV/Vis spectroscopy; the batch-specific certificate of analysis is available before purchase. For research use only. Not for use in or on the human body.