Buy AHK-Cu

Buy AHK-Cu – AHK-Cu is a copper-binding tripeptide with the sequence alanyl-histidyl-lysine, which coordinates a divalent copper ion in a square-planar complex via the histidine imidazole ring and neighbouring backbone nitrogen atoms. It belongs to the metallopeptides and is a close structural analogue of the better-known GHK-Cu, in which glycine occupies the first position. In basic research AHK-Cu serves as a model substance for tracing copper transfer between low-molecular-weight ligands and serum proteins; fibroblast and keratinocyte cultures show how copper-containing tripeptides alter expression of extracellular matrix components and copper-dependent enzymes. The literature likewise describes the redox chemistry of the coordinated copper ion in cell-free test systems. Practically relevant is the blue-violet colour of the complex, which permits photometric monitoring of complex formation; stability is pH-dependent and falls in acidic conditions in favour of free copper ions, so buffer choice and preparation conditions should be documented. Peptélia supplies AHK-Cu as a lyophilisate in a vial, with reconstitution and storage details on the product page; it is classified under Skin and Cell Research, directly alongside the related category GHK-Cu. Each batch is tested in-house by HPLC and UV/Vis spectroscopy; the batch-specific certificate of analysis is available before purchase. For research use only. Not for use in or on the human body.