Buy DSIP

Buy DSIP – Delta Sleep-Inducing Peptide is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from cerebral venous blood and since described as an endogenous neuromodulatory factor without a clearly assigned receptor. In basic research DSIP serves as a model substance for addressing the question of a specific binding partner in the CNS: work covers binding studies on membrane preparations from brain tissue, effects on the release of corticotropin and somatoliberin in pituitary cell cultures, and electrophysiological recordings from thalamocortical slice preparations. The literature likewise discusses interaction with monoaminergic and GABAergic pathways in rodent models. Notable is the pronounced peptidase sensitivity: the unstructured, hydrophilic sequence is rapidly cleaved in plasma, so in vitro work often uses protease inhibitors or shortened analogues such as DSIP-NH2. The peptide dissolves well in aqueous buffers; strongly acidic or alkaline conditions are avoided because of the Asp and Glu residues. Peptélia supplies DSIP as a lyophilisate in a vial, with reconstitution and storage details on the product page. Further compounds for central nervous questions are found under Neurocognitive Research. Each batch is tested in-house by HPLC and UV/Vis spectroscopy; the batch-specific certificate of analysis is available before purchase. For research use only. Not for use in or on the human body.