Buy SLU-PP-332

Buy SLU-PP-332 – SLU-PP-332 is a synthetic, non-peptidic compound belonging to the class of pan-agonists of the estrogen-related receptors (ERRα, ERRβ and ERRγ). These nuclear receptors have no known endogenous ligand and act as constitutively active transcription factors that, together with the PGC-1 coactivators, regulate genes of oxidative phosphorylation. In basic research SLU-PP-332 is employed as a chemical probe to separate ERR-dependent transcription from classical estrogen receptor signalling. Reported applications include the induction of mitochondrial biogenesis markers in muscle cell cultures, changes in respiratory chain capacity measured in respirometry setups, and questions around fibre type switching in skeletal muscle models. One practical detail concerns handling: as a lipophilic small molecule the compound has limited solubility in aqueous buffers and is usually prepared as a DMSO stock solution, keeping the solvent fraction in the assay low and accounting for it with a vehicle control. Peptélia supplies SLU-PP-332 as a lyophilisate in a vial, with reconstitution and storage details on the product page. It is classified under Metabolic Research, where further cellular metabolism targets can be compared. Each batch is tested in-house by HPLC and UV/Vis spectroscopy, and the batch-specific certificate of analysis is viewable before purchase. For research use only. Not for use in or on the human body.